Pathogenic / Pathogenic organelles
Organelles
Base effects for an unprefixed organelle. Parentheses and the overcharge line show the bonus per 1× overcharge; run-wide mutations and accumulated bonuses are excluded. Choose a rarity to compare the same catalogue.
| Organelle | Effects | Unlock & connection role |
|---|---|---|
| Mitochondrion After slashing an enemy projectile: | No achievement conditionOvercharge generator | |
| External Flexible energy lash | Base effect200 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Spawns a single heavy melee minion | Base effect10 HP Downstream effectMinion's attacks gain bonuses from downstream infusers | No achievement condition |
| Internal Enemies killed by affected attacks explode | Base effect800 explosion damage (+800) Per 1× overcharge+800 explosion damage Downstream effectThe death explosion gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports ExcitableUse in chain planner → |
| Internal Projectiles home in on enemies | Per 1× overcharge+50% homing power | No achievement conditionProjectile infuser · Supports Excitable |
| Internal Permanently gains damage when recycling organelles | Base effectCurrently -20% damage Per 1× overchargeDoubles damage gained from recycling | No achievement conditionAttack infuser |
| Mitochondrion · Active ability Press the active ability button to sacrifice 1 HP and 2× overcharge for 6s | Beat the Stomach without ever dropping below 6 HPOvercharge generator | |
| External · Active ability Press the active ability button to lash rapidly at nearby enemies | Base effect630 damage per second for 5s | No achievement conditionSupports Excitable |
| External Shoots a multiplying virus | Base effectStronger bacteriophages spawn when they kill Per 1× overcharge+30% attack speed Downstream effectMinion's attacks gain bonuses from downstream infusers | No achievement conditionWeapon · Supports Excitable |
| Movement Fires projectiles backwards while sprinting (hold dodge) | Base effect171 damage per second Per 1× overcharge+30% attack speed Downstream effectThe bullets gain bonuses from downstream infusers | No achievement condition |
| Mitochondrion | Base effectAfter each kill: | No achievement conditionOvercharge generator |
| Internal Splits attacks into two | Base effect-5% damage Per 1× overcharge2x narrower angle Downstream effectA random attack of the two gets bonuses from downstream infusers | Equip 2 identical Epic or higher organelles simultaneouslyAttack infuser · Projectile infuser · Supports ExcitableUse in chain planner → |
| External Heavy artillery | Base effect176 damage per second Additional effectExplosions hurt the player Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| External Slow but powerful circular melee attack | Base effect90 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| External Fast shooting gun | Base effect62 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| External SENSES HIDDEN CHAMBERS. UNFOLDS AND POINTS TOWARD THE NEAREST SECRET WHEN OVERCHARGED. | No achievement condition | |
| External Blocks incoming attacks | Base effect3x Overcharge for 1s when blocking a projectile | No achievement conditionOvercharge generator |
| External · Active ability Press the active ability button to fire a laser in its slot's direction for 2s | Base effect800 damage per second Downstream effectThe laser beam gets bonuses from downstream infusers | No achievement condition |
| Internal · Active ability Press the active ability button to fire a laser beam for 2s | Base effect1000 damage per second Downstream effectThe laser beam gets bonuses from downstream infusers | No achievement condition |
| Internal Attacks improve over time as they travel | Base effect+25% damage every 0.5s (+30% faster) Per 1× overcharge+30% faster triggering time Downstream effectEvery 0.5s, attacks gain bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal · Active ability Press the active ability button to perform a dash attack | Base effectDeals 250 damage when ramming | No achievement condition |
| External Fires 5 short range shots | Base effect13 damage per second Per 1× overcharge+1 shots | No achievement conditionWeapon · Supports Excitable |
| External Harpoon that binds enemies to walls | Base effect50 damage per second Additional effectPierces 1 times Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal · Active ability Press the active ability button to spray 10 attacks of each connected weapon in a cone | Downstream effectEach attack gets bonuses from downstream infusers | No achievement condition |
| External Low damage, slams enemies into walls | Base effect39 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Movement When dodging, freezes nearby enemies | Additional effectFreezes for 1s and deals 20 damage Per 1× overcharge+50% freeze size | No achievement condition |
| External Continuous beam that freezes enemies held in it | Base effect25 damage per second Additional effect+0% range Per 1× overcharge+2s freeze duration | No achievement conditionWeapon · Supports Excitable |
| External Freezes nearby enemies on contact | Base effect0.2s freeze every 0.3s (+0.2s) Additional effect+0% max length Per 1× overcharge+0.2s freeze duration | No achievement conditionSupports Excitable |
| Internal · Active ability Press the active ability button to release a pulse that erases projectiles and freezes enemies | Base effectFreezes for 2s Downstream effectThe freezing pulse gains bonuses from downstream infusers | No achievement condition |
| Internal Attacks have a chance to freeze | Base effect6% freeze chance (+5%) Per 1× overcharge+5% freeze chance Downstream effectFreezing attacks gain bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal Prevents death once and explodes | Base effectRestores 1 HP (+1) Per 1× overchargeRestore +1 HP | No achievement condition |
| External Spawns a powerful mine | Base effect90 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| External Launches bombs that explode on enemy contact | Base effect112 damage per second Additional effectExplosions hurt the player Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Backstabs deal +100% damage | Per 1× overcharge+100% damage on backstab Downstream effectBackstabs gain bonuses from downstream infusers | No achievement conditionAttack infuser · Supports Excitable |
| Internal Attacks deal splash damage on impact | Base effect35% splash damage Per 1× overcharge+40% splash size Downstream effectThe splash attack gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal Projectiles bounce off walls and enemies | Base effectBounces 1 time(s) (+1) Per 1× overcharge+1 bounce Downstream effectAfter each bounce, projectiles gain bonuses from downstream infusers | No achievement conditionProjectile infuser · Supports Excitable |
| Mitochondrion | Base effectAfter dodging through a projectile: | No achievement conditionOvercharge generator |
| Internal +1 max HP | Per 1× overcharge+15% chance to spawn a heart when finishing a room | No achievement condition |
| Mitochondrion | Base effectWhen starting a room: | No achievement conditionOvercharge generator |
| Internal Hold to charge, release to burst attacks from connected weapons | Base effect2s max charge time (+50% charge speed) Additional effect+0% extra attacks Per 1× overcharge+50% charge speed Downstream effectFully charged bursts gain bonuses from downstream infusers | No achievement conditionSupports Excitable |
| Internal · Active ability Press the active ability button to explode and deal 1000 damage to nearby enemies | Base effect+0% size | No achievement condition |
| Internal Increases range of projectiles, melee attacks and areas of effect | Base effect+50% range (+50%) Per 1× overcharge+50% range | No achievement conditionAttack infuser · Supports Excitable |
| Movement Provides movement | Base effect5 thrust (+50%) Per 1× overcharge+50% speed | No achievement condition |
| External Links enemies together | Base effect40 damage per second Additional effectPierces 1 times Per 1× overcharge+30% attack speed | Pierce 6 times with a single attackWeapon · Supports Excitable |
| External Emits volatile electric arcs | Base effect67 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Movement When dashing, unleashes arcs of lightning | Base effectEmits 3 arcs dealing 48 damage each (+48) Per 1× overcharge+48 arc damage Downstream effectThe arcs get bonuses from downstream infusers | No achievement condition |
| Internal Attacks have a chance to arc to nearby enemies | Base effect50% arc damage Per 1× overcharge+30% chance to arc Downstream effectThe arc gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal · Active ability Press the active ability button to plant a beacon that arcs between you and other beacons | Base effectBeacon lasts 15s Downstream effectThe lightning beams get bonuses from downstream infusers | No achievement condition |
| Internal Discharges accumulated electricity to nearby enemies | Base effect20 damage Per 1× overchargeAccumulates an additional charge every 0.3s | No achievement conditionSupports Excitable |
| Internal Attacks arc to other affected attacks | Base effect70% arc damage (+40%) Per 1× overcharge+40% arc damage Downstream effectThe arc gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Mitochondrion Orbiting arc that blocks enemy projectiles | Base effect50° arc size | No achievement conditionOvercharge generator |
| Internal | Base effectConnected weapons no longer consume stamina Per 1× overchargeCharges 20% stamina per second | No achievement conditionSupports Excitable |
| Internal Transfers attacks from melee weapons into projectiles | Base effect-10% damage of melee attacks Per 1× overcharge+30% attack speed of melee weapons Downstream effectMelee attacks gain bonuses from downstream infusers | Equip 3 melee and 3 ranged weapons at the same timeProjectile infuser · Supports Excitable |
| External Long range shredding sawblade | Base effect150 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Projectiles orbit the organelle | Base effect+2 pierces (+1) Per 1× overcharge+1 pierces Downstream effectEach lap around the organelle, projectiles gain bonuses from downstream infusers | No achievement conditionProjectile infuser · Supports Excitable |
| External Drill that takes time to spin up | Base effect90 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal · Active ability Press the active ability button to become invulnerable and reflect projectiles for 4s | Base effectReflected projectiles deal 100 damage Downstream effectReflected projectiles gain bonuses from downstream infusers | No achievement condition |
| Internal Attacks have a chance to deal a critical strike | Base effect10% chance (+10%) to deal 2× damage Per 1× overcharge+10% critical chance Downstream effectCritical strikes gain bonuses from downstream infusers | No achievement conditionAttack infuser · Supports Excitable |
| External Pushes nearby enemies away | Base effect10 damage per second Additional effect+0% knockback Per 1× overcharge+50% knockback | No achievement conditionSupports Excitable |
| Internal Orbiting blade strikes nearby enemies | Base effect340 damage per second Additional effect+0% blade size Per 1× overcharge+250% rotation speed, +50% attack speed Downstream effectStrikes gain bonuses from downstream infusers | No achievement condition |
| External Slashing melee weapon | Base effect90 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal On hit, fires two perpendicular lasers | Base effect100% laser damage (+40%) Per 1× overcharge+40% laser damage Downstream effectThe side lasers gain bonuses from downstream infusers | No achievement conditionAttack infuser · Supports ExcitableUse in chain planner → |
| External Shoots 2 short-range projectiles sideways | Base effect144 damage per second Additional effectCannot aim Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| External Sustained beam while held | Base effect80 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Projectiles are pulled towards the organelle | Base effect+3 pierces (+1) Per 1× overcharge+1 pierces Downstream effectWhen projectiles pass through the organelle, they gain bonuses from downstream infusers | No achievement conditionProjectile infuser · Supports Excitable |
| Mitochondrion | Base effectAfter taking a pickup: | No achievement conditionOvercharge generator |
| Internal Spawns a minion that shares connected weapons | Base effect7 HP Downstream effectMinion's attacks gain bonuses from downstream infusers | Equip 3 minion spawning organelles at the same time |
| External Spews a slow orb of continuous damage | Base effect67 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal | Base effectCreates 4x DNA after | No achievement condition |
| Internal · Active ability Press the active ability button to explode gibs of dead enemies | Base effect+0% size Additional effectExplosions deal 200 damage | No achievement condition |
| External Shoots out a melee minion | Base effect2 HP Per 1× overcharge+30% attack speed Downstream effectMinion's attacks gain bonuses from downstream infusers | No achievement conditionWeapon · Supports Excitable |
| External · Active ability Press the active ability button to launch a shield that reflects enemy shots back | Base effectReflects 16 enemy shots Downstream effectReflected projectiles gain bonuses from downstream infusers | No achievement condition |
| Internal Attacks blast a cone behind hit enemies | Base effect80% cone damage (+40% size) Per 1× overcharge+40% cone size Downstream effectThe cone blast gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal Creates an orbiting arc that improves attacks that pass through | Base effect+30% damage to attacks passing through Per 1× overcharge+60° arc angle Downstream effectAttacks passing through gain bonuses from downstream infusers | No achievement condition |
| Internal | Base effectCreates 3x cores after | No achievement condition |
| Internal | Base effectSpawns 1 armor after | No achievement condition |
| External Spews piercing, burning acid | Base effect23 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Improves damage | Base effect+25% damage (+40%) Per 1× overcharge+40% damage | No achievement conditionAttack infuser · Supports ExcitableUse in chain planner → |
| External Piercing melee weapon | Base effect71 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Attacks pierce through enemies | Base effect+40% damage after each pierce (+40%) Per 1× overcharge+40% damage after each pierce Downstream effectAfter each pierce, the attacks gain bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal Attacks explode on impact, damaging enemies and the player | Base effect200% explosion damage (+100%) Per 1× overcharge+100% explosion damage Downstream effectThe explosion gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal · Active ability Press the active ability button to consume a random equipped organelle for +40% permanent damage | Base effect+0% damage | Recycle 16 organelles in a single runAttack infuser |
| Internal When an affected attack kills an enemy, permanently gain damage | Base effect-20% damage Per 1× overcharge+0.25% permanent damage gain on kill | Kill 1000 enemiesAttack infuser · Supports Excitable |
| Internal Connected weapons automatically attack the closest enemy | Base effectAuto-attacks don't use stamina Additional effect0% larger area of detection Per 1× overcharge+50% attack speed | No achievement conditionSupports Excitable |
| External Precise with high kinetic power | Base effect56 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Mitochondrion | Base effectAfter finishing a room | No achievement conditionOvercharge generator |
| Internal · Active ability Press the active ability button to shoot out a circle of 30 attacks of each connected weapon | Downstream effectEach attack gets bonuses from downstream infusers | No achievement condition |
| External Fires a 3 shot burst | Base effect27 damage per second Per 1× overcharge+1 shots | No achievement conditionWeapon · Supports Excitable |
| External · Active ability Press the active ability button to launch a bouncing fireball that bursts | Base effect250 burn per second Downstream effectThe fireball and burn get bonuses from downstream infusers | No achievement condition |
| Movement Leaves a burning trail when dodging | Base effectTrail applies 7 burn (+7) every 1s Per 1× overcharge+7 burn Downstream effectThe burn effect gets bonuses from downstream infusers | No achievement condition |
| Internal Attacks apply burn | Base effectApply 4 burn (+4) Per 1× overcharge+4 burn Downstream effectThe burn effect gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Mitochondrion | Base effectAfter 10 successful attacks from connected organelles: | No achievement conditionOvercharge generator |
| Internal | Base effectUpgrades the rarity of a random organelle after being overcharged for 120s | Equip 3 Legendary organelles simultaneously |
| Internal | Base effectSpawns 1 HP after | No achievement condition |
| Internal Attacks reflect enemy projectiles | Base effect6% chance for projectiles (+15%) Per 1× overcharge+15% chance Downstream effectReflected projectiles gain bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| Internal Improves attack speed after each hit, decreases on a miss | Base effect+2% attack speed for each hit (+2%) Per 1× overcharge+2% attack speed for each hit Downstream effectWhen attack speed is charged to maximum, attacks gain bonuses from downstream infusers | Reach +150% attack speed on a weaponSupports Excitable |
| External Can only shoot when overcharged | Base effect225 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon |
| Internal Attacks break into shrapnel on hit | Base effectCreates 2 shrapnel projectiles Per 1× overcharge+30% shrapnel damage Downstream effectShrapnel gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| External Fires 10 medium range shots | Base effect9 damage per second Per 1× overcharge+2 shots | No achievement conditionWeapon · Supports Excitable |
| Internal · Active ability Press the active ability button to spawn a turret | Base effect4 HP Downstream effectTurret attacks gain bonuses from downstream infusers | No achievement condition |
| Internal · Active ability Press the active ability button to reroll reward pedestals | Collect 100 rewards from pedestals in total | |
| Internal Attacking when synced to music gives bonus damage | Base effect+200% damage at the start of a bar Per 1× overchargeTiming is more forgiving Downstream effectWhen timing is extra precise, attacks gain bonuses from downstream infusers | No achievement conditionAttack infuser · Supports Excitable |
| External Slow-firing but powerful | Base effect63 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Lowers damage unless overcharged | Base effect-40% damage (+160%) Per 1× overcharge+160% damage | Reach 5× overcharge on a single organelleAttack infuser · Supports Excitable |
| External Lobs a delayed cross of lasers | Base effect0 damage per second Additional effectLasers hurt the player Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| External Fast, short-range melee attack | Base effect133 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal · Active ability Press the active ability button to spawn a fast shooting minion | Base effect2 HP Downstream effectMinion attacks gain bonuses from downstream infusers | No achievement condition |
| External Reaches out to heal and empower your minions | Base effect+200% damage to connected minions Downstream effectBuffed minion attacks get bonuses from downstream infusers | No achievement condition |
| Internal Affected attacks explode when dashing | Base effectExplosions deal 80% damage Additional effect+0% splash size (+50%) Per 1× overcharge+50% splash size Downstream effectThe explosion gets bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| External A piercing laser of pure heat | Base effect45 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Movement Leaves a toxic trail | Additional effectDeals 5 damage every 0.5s Per 1× overcharge+50% toxin duration Downstream effectToxins gain bonuses from downstream infusers | No achievement condition |
| Internal Attacks leave a toxic trail | Base effect+0% toxin size Additional effectToxins deal 3 damage every 0.5s Per 1× overcharge+50% toxin duration Downstream effectToxins gain bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports Excitable |
| External Third attack deals 3x damage | Base effect67 damage per second Per 1× overcharge+30% attack speed | No achievement conditionWeapon · Supports Excitable |
| Internal Triples attacks | Base effectExtra attacks deal 25% damage (+25%) Per 1× overcharge+25% damage of extra attacks Downstream effectExtra attacks gain bonuses from downstream infusers | No achievement conditionAttack infuser · Projectile infuser · Supports ExcitableUse in chain planner → |
| External While connected to an enemy: | Base effect20 damage per second Additional effect+0% max length | No achievement conditionOvercharge generator |
| Internal Increases damage every second not attacking | Base effect-30% base damage Per 1× overcharge+50% damage every second Downstream effectWhen damage is charged to maximum, attacks gain bonuses from downstream infusers | Deal 5000 damage in a single hitAttack infuser · Supports Excitable |
| Mitochondrion · Active ability Press the active ability button to release 5s of stored overcharge | Generate 5000 seconds of charge timeOvercharge generator | |
| Mitochondrion | Base effectAfter getting hit: | No achievement conditionOvercharge generator |
| Mitochondrion Conduit that passes on effects of connected organelles | Base effect0% chance to trigger connected attack infusers twice Per 1× overchargeOvercharge connected organelles Downstream effectEach attack gets bonuses from downstream infusers | Take 2 items from a single sacrifice roomAttack infuser · Projectile infuser · Overcharge generator · Weapon |
| Internal Attacks create vortexes that pull enemies in | Base effect10% chance to create a vortex (+50% area) Additional effect+0% base area Per 1× overcharge+50% vortex area Downstream effectThe vortex gets bonuses from downstream infusers | No achievement conditionAttack infuser · Supports Excitable |
Checked October 3, 2026. Sources & coverage. Unofficial.